The team's debut takes place as "Pramac Honda Racing" in 2002 in MotoGP with Tetsuya Harada , aboard a Honda NSR500 with Dunlop tires,

In 2005 the Pramac team and the d'Antín team, born in 1999 in Spain and founded by the driver Luis d'Antí n , a team that had competed the first year in the 250 class and then passed from 2000 to the 500 class , join in a single formation, the team called Pramac d'Antín, which participates in competitions with Ducati motorcycles, presents at the start only one motorbike driven by Roberto Rolfo .

In the 2019 season the team fielded the reconfirmed Jack Miller , on a GP19, and Francesco Bagnaia , champion of the Moto2 class in 2018, on a GP18. Miller obtained five third places in the season while Bagnaia obtained a fourth place in the Australian Grand Prix as his best result, taking Pramac to sixth place in the team standings. In the 2020 season the team will field the two riders of the previous year, Miller and Bagnaia who conquered podium placements, contributing to Ducati's conquest of the constructors' title

In the 2021 world championship, the drivers are Johann Zarco and Jorge Martìn

MotoE

Pramac Racing participates in the inaugural edition of the MotoE class World Cup, fielding two Energica Egos entrusted to the Australian Joshua Hook and Alex De Angelis , who close the season respectively in thirteenth and seventh place in the standings. The best result of the season is the pole position conquered by De Angelis in the Misano Grand Prix . In 2020 Pramac Racing continues with the two drivers of the previous year, Hook and De Angelis, who closed the season in eighth and fourteenth place.